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h , Doseresponse curves for control (sgCtrl) and CRBN KO (sgCRBN) HCT116 cells treated with SMART1 or SMART1Et for 72 h (4 independent experiments)

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[7] Clinicians should exercise extreme caution in advanced chronic kidney disease or sarcoidosis, tuberculosis, and other granulomatous disorders where extrarenal 1-hydroxylase activity can generate excess calcitriol and precipitate hypercalcaemia even at modest serum 25-hydroxyvitamin D concentrations

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